Liver T Cell Trapping in + TLR - 4 Regulates CD 8

of June 13 , 2017 . This information is current as the Liver T Cell Trapping in + TLR - 4 Regulates CD 8

This information is current as the Liver T Cell Trapping in + TLR - 4 Regulates CD 8 Beena

T Cell Trapping in + TLR - 4 Regulates CD 8

TLR-4 regulates CD8+ T cell trapping in the liver.

Mammalian TLRs are understood primarily as an activating system for innate and adaptive immunity, but have also been implicated in sensing cellular damage and in promoting intestinal integrity. In this study we show that TLR-4 also controls the in vivo distribution of activated CD8+ T cells. The liver is a site for trapping and apoptosis of activated CD8+ T cells during systemic immune response...

Maturation State and Function of Monocyte Derived Dendritic Cells in Liver Transplant Recipients

Background: Dendritic cells (DCs) are potent antigen presenting cells for triggering of the immune reaction post transplantation. These cells are centrally involved in the initiation of T cell-dependent immune responses. Objective: To compare the level of DC maturation and function in liver transplant recipients with healthy controls. Methods: In this study, twelve peripheral blood samples we...